GENETIC MECHANISMS OF CO-EMERGENCE OF INH-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS DURING THE STANDARD COURSE OF ANTITUBERCULOSIS THERAPY

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy

ABSTRACTThe incidence of isoniazid (INH) resistant Mycobacterium tuberculosis is increasing globally.This study aimed to identify the molecular mechanisms behind the development of INH resistance in M.tuberculosis strains collected from the same patients during the Baby Blankets standard course of treatment.Three M.tuberculosis strains were collect

read more


A Markov blanket-based method for detecting causal SNPs in GWAS

Abstract Background Detecting epistatic interactions associated with complex and common diseases can help to improve prevention, diagnosis and treatment of these diseases.With the development of genome-wide association studies (GWAS), designing powerful and robust computational method for identifying epistatic interactions associated Yarrow Flowers

read more


Understanding Gender Equality Policy and Practice Gaps Through the Lens of Organisational Justice: Development of an Employee Alignment Model

Policies and actions to address gender inequalities are widespread across a range of institutional and organisational contexts.Concerns have been raised about the efficacy and impacts of such measures in the absence of sustained evaluation of these activities.It has been proposed that important contextual factors may propel or inhibit measures to p

read more